Potent antitumor activity of a glutamyltransferase-derived peptide via an activation of oncosis pathway.

ABSTRACT: Hepatocellular carcinoma (HCC) still presents poor prognosis with high mortality rate, despite of the improvement in the management. The challenge for precision treatment was due to the fact that little targeted therapeutics are available for HCC. Recent studies show that metabolic and circulating peptides serve as endogenous switches for correcting aberrant cellular plasticity. Here we explored the antitumor activity of low molecular components in human umbilical serum and identified a high abundance peptide VI-13 by peptidome analysis, which was recognized as the part of glutamyltransferase signal peptide. We modified VI-13 by inserting four arginines and obtained an analog peptide VI-17 to improve its solubility. Our analyses showed that the peptide VI-17 induced rapid context-dependent

SUBMITTER: Fang C 

PROVIDER: S-EPMC8363616 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature