Ontology highlight
ABSTRACT:
SUBMITTER: Moreira TG
PROVIDER: S-EPMC8363668 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Moreira Thais G TG Mangani Davide D Cox Laura M LM Leibowitz Jeffrey J Lobo Eduardo L C ELC Oliveira Mariana A MA Gauthier Christian D CD Nakagaki Brenda N BN Willocq Valerie V Song Anya A Guo Lydia L Lima David C A DCA Murugaiyan Gopal G Butovsky Oleg O Gabriely Galina G Anderson Ana C AC Rezende Rafael M RM Faria Ana Maria C AMC Weiner Howard L HL
Nature communications 20210813 1
The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are important in maintaining gut homeostasis. Here, we investigate DC transcriptome, phenotype and function in five anatomical locations of the gut lamina propria (LP) which constitute different antigenic environments. We show that DC from distinct gut LP compartments induce distinct T cell differentiation and cytokine secretion. We also find ...[more]