Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study.

ABSTRACT:

Introduction

Intravenous lipid emulsions (ILE) have been credited for successful resuscitation in drug intoxication cases where other cardiac life-support methods have failed. However, inter-individual variability can function as a confounder that challenges our ability to define the scope of efficacy for lipid interventions, particularly as relevant data are scarce. To address this challenge, we developed a quantitative systems pharmacology model to predict outcome variability and shed light on causal mechanisms in a virtual population of rats subjected to bupivacaine toxicity and ILE intervention.

Materials and methods

We combined a physiologically based pharmacokinetic-pharmacodynamic model with data from a small study in Sprague-Dawley rats to characterize individual-spe

SUBMITTER: McDaniel M 

PROVIDER: S-EPMC8363697 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature