RSPO3 is important for trabecular bone and fracture risk in mice and humans.
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ABSTRACT:
SUBMITTER: Nilsson KH
PROVIDER: S-EPMC8363747 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nilsson Karin H KH Henning Petra P El Shahawy Maha M Nethander Maria M Andersen Thomas Levin TL Ejersted Charlotte C Wu Jianyao J Gustafsson Karin L KL Koskela Antti A Tuukkanen Juha J Souza Pedro P C PPC Tuckermann Jan J Lorentzon Mattias M Ruud Linda Engström LE Lehtimäki Terho T Tobias Jon H JH Zhou Sirui S Lerner Ulf H UH Richards J Brent JB Movérare-Skrtic Sofia S Ohlsson Claes C
Nature communications 20210813 1
With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here we show that the fracture reducing allele at the RSPO3 locus associate with increased RSPO3 expression both at the mRNA and protein levels, increased trabecular bone mineral density and reduced risk mainly of distal forearm f ...[more]
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