PathExNET: A tool for extracting pathway expression networks from gene expression statistics.

ABSTRACT: A fundamental issue related to the understanding of the molecular mechanisms, is the way in which common pathways act across different biological experiments related to complex diseases. Using network-based approaches, this work aims to provide a numeric characterization of pathways across different biological experiments, in the prospect to create unique footprints that may characterise a specific disease under study at a pathway network level. In this line we propose PathExNET, a web service that allows the creation of pathway-to-pathway expression networks that hold the over- and under expression information obtained from differential gene expression analyses. The unique numeric characterization of pathway expression status related to a specific biological experiment (or disease), as we

SUBMITTER: Minadakis G 

PROVIDER: S-EPMC8363825 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature