Nabe: an energetic database of amino acid mutations in protein-nucleic acid binding interfaces.

ABSTRACT: Protein-nucleic acid complexes play essential roles in regulating transcription, translation, DNA replication, repair and recombination, RNA processing and translocation. Site-directed mutagenesis has been extremely useful in understanding the principles of protein-DNA and protein-RNA interactions, and experimentally determined mutagenesis data are prerequisites for designing effective algorithms for predicting the binding affinity change upon mutation. However, a vital challenge in this area is the lack of sufficient public experimentally recognized mutation data, which leads to difficulties in developing computational prediction methods. In this article, we present Nabe, an integrated database of amino acid mutations and their effects on the binding free energy in protein-DNA and protein

SUBMITTER: Liu J 

PROVIDER: S-EPMC8363842 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature