MiR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers.

ABSTRACT:

Objectives

Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patients exhibiting more aggressive forms of vascular disease and poorer outcomes after surgery. Kv1.3 channels are critical players in VSMC proliferation. Kv1.3 blockers inhibit VSMCs MEK/ERK signalling and prevent vessel restenosis. We hypothesize that dysregulation of microRNAs (miR) play critical roles in adverse remodelling, contributing to Kv1.3 blockers efficacy in T2DM VSMCs.

Methods and results

We used clinically relevant in vivo models of vascular risk factors (VRF) and vessels and VSMCs from T2DM patients.

Resukts

Huma

SUBMITTER: Arevalo-Martinez M 

PROVIDER: S-EPMC8363881 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature