Association of Preterm Birth With Myocardial Fibrosis and Diastolic Dysfunction in Young Adulthood.

ABSTRACT:

Background

Preterm birth affects about 10% of live births worldwide and is associated with cardiac alterations. Animal models of preterm birth suggest that left ventricular functional impairment may be due to an up-regulation of myocardial fibrosis.

Objectives

The aim of this study was to determine whether diffuse left ventricular fibrosis is evident in young adults born preterm.

Methods

One hundred one normotensive young adults born preterm (n = 47, mean gestational age 32.8 ± 3.2 weeks) and term (n = 54) were included from YACHT (Young Adult Cardiovascular Health sTudy). Left ventricular structure and function were quantified by cardiovascular magnetic resonance and echocardiography. Intravenous administration of a gadolinium-based contrast agent during cardiovascul

SUBMITTER: Lewandowski AJ 

PROVIDER: S-EPMC8363934 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature