Potential genes and pathways associated with heterotopic ossification derived from analyses of gene expression profiles.

ABSTRACT:

Background

Heterotopic ossification (HO) represents pathological lesions that refer to the development of heterotopic bone in extraskeletal tissues around joints. This study investigates the genetic characteristics of bone marrow mesenchymal stem cells (BMSCs) from HO tissues and explores the potential pathways involved in this ailment.

Methods

Gene expression profiles (GSE94683) were obtained from the Gene Expression Omnibus (GEO), including 9 normal specimens and 7 HO specimens, and differentially expressed genes (DEGs) were identified. Then, protein-protein interaction (PPI) networks and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed for further analysis.

Results

In total, 275 DEGs were differentially expres

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8364104 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature