Tau-related grey matter network breakdown across the Alzheimer's disease continuum.

ABSTRACT:

Background

Changes in grey matter covariance networks have been reported in preclinical and clinical stages of Alzheimer's disease (AD) and have been associated with amyloid-β (Aβ) deposition and cognitive decline. However, the role of tau pathology on grey matter networks remains unclear. Based on previously reported associations between tau pathology, synaptic density and brain structural measures, tau-related connectivity changes across different stages of AD might be expected. We aimed to assess the relationship between tau aggregation and grey matter network alterations across the AD continuum.

Methods

We included 533 individuals (178 Aβ-negative cognitively unimpaired (CU) subjects, 105 Aβ-positive CU subjects, 122 Aβ-positive patients with mild cognitive impairment, a

SUBMITTER: Pelkmans W 

PROVIDER: S-EPMC8364121 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature