Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer.

ABSTRACT: BACKGROUND Colorectal cancer (CRC) is the second most deadly cancer in the world according to GLOBOCAN 2020 data. Accumulating evidence suggests that RNA methylation modification is also misregulated in human cancers and may be a potential ideal target for cancer treatment. MATERIAL AND METHODS m6A-related differentially expressed genes (DEGs) were identified from colon adenocarcinoma and rectum adenocarcinoma esophageal carcinoma patients with different pathological stages. The protein-protein interaction (PPI) network construction, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DEGs were conducted. Cox regression analysis was applied to the screening of m6A-related DEGs significantly associated with the overall survival (OS), and tho

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8364289 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature