Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity.

ABSTRACT: Despite the high prevalence of obesity, little is known about its potential impact on the pharmacokinetics of psychotropic drugs. In the course of investigating the role of the microRNA system on neuronal signaling, we found that mice lacking the translin/trax microRNA-degrading enzyme display an exaggerated locomotor response to amphetamine. As these mice display robust adiposity in the context of normal body weight, we checked whether this phenotype might reflect elevated brain levels of amphetamine. To assess this hypothesis, we compared plasma and brain amphetamine levels of wild type and Tsn KO mice. Furthermore, we checked the effect of diet-induced increases in adiposity on plasma and brain amphetamine levels in wild type mice. Brain amphetamine levels were higher in Tsn KO mice tha

SUBMITTER: Fu X 

PROVIDER: S-EPMC8364554 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature