Targeting of IL-10R on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.

ABSTRACT: Acute myeloid leukemia (AML) is a biologically and clinically heterogeneous disease with a dismal prognosis and limited treatment options. Chimeric antigen receptor (CAR) T cells have achieved unprecedented clinical responses in patients with B cell malignancies but a dismal consequences in AML. In our previous study, we found that interleukin-10 receptor (IL-10R) was overexpressed in most AML cells, and played an important role in promoting the stemness of leukemia cells. In this study, we developed a novel ligand-based CAR-T cell targeting IL-10R, which displayed striking cytotoxicity both in vitro and in vivo against AML cells. Except for monocytes, it had no significant adverse effects on the normal hematopoietic system, including CD34⁺ hematopoietic stem and progenitor cell

SUBMITTER: Chen N 

PROVIDER: S-EPMC8364556 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature