Slower response to treatment of iron-deficiency anaemia in pregnant women infected with HIV: a prospective cohort study.

ABSTRACT:

Objective

Antenatal anaemia is associated with increased peripartum transfusion requirement in South Africa. We studied whether HIV was associated with the response to treatment of iron-deficiency anaemia.

Design

Prospective cohort study.

Setting

Hospital-based antenatal anaemia clinic in South Africa.

Sample

Equal-sized cohorts of pregnant women testing positive for HIV (HIV+) and testing negative for HIV (HIV-) with iron-deficiency anaemia.

Methods

Haemoglobin trajectories of women with confirmed iron-deficiency anaemia (ferritin < 50 ng/ml) were estimated from the initiation of iron supplementation using mixed-effects modelling, adjusted for baseline HIV status, ferritin level, maternal and gestational ages and time-varying iron supplementation.

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SUBMITTER: Hull JC 

PROVIDER: S-EPMC8364561 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature