Imaging angiogenesis in atherosclerosis in large arteries with ⁶⁸Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.

ABSTRACT:

Background

Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of ⁶⁸Ga-NODAGA-RGD, a specific α_vβ₃ integrin ligand for PET.

Materials and methods

The data of 44 patients who underwent ⁶⁸Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed semi-quantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with clinically documented atherosclerotic cardiovascular disease, cardiovascular ris

SUBMITTER: Dietz M 

PROVIDER: S-EPMC8364589 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature