Development and validation of a novel survival model for acute myeloid leukemia based on autophagy-related genes.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is one of the most common blood cancers, and is characterized by impaired hematopoietic function and bone marrow (BM) failure. Under normal circumstances, autophagy may suppress tumorigenesis, however under the stressful conditions of late stage tumor growth autophagy actually protects tumor cells, so inhibiting autophagy in these cases also inhibits tumor growth and promotes tumor cell death.

Methods

AML gene expression profile data and corresponding clinical data were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, from which prognostic-related genes were screened to construct a risk score model through LASSO and univariate and multivariate Cox analyses. Then the model was verified in the TCG

SUBMITTER: Huang L 

PROVIDER: S-EPMC8364747 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature