The effect of delays in second-dose antibiotics on patients with severe sepsis and septic shock.

ABSTRACT:

Background

Early antibiotics are fundamental to sepsis management. Second-dose antibiotic delays were associated with increased mortality in a recent study. Study objectives include: 1) determine factors associated with delays in second-dose antibiotic administration; 2) evaluate if delays influence clinical outcomes.

Methods

ED-treated adults (≥18 years; n = 1075) with severe sepsis or septic shock receiving ≥2 doses of intravenous antibiotics were assessed, retrospectively, for second-dose antibiotic delays (dose time > 25% of recommended interval). Predictors of delay and impact on outcomes were determined, controlling for MEDS score, 30 mL/kg fluids and antibiotics within three hours of sepsis onset, lactate, and renal failure, among others.

Results

In total, 335

SUBMITTER: Lykins V JD 

PROVIDER: S-EPMC8364855 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature