SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma.

ABSTRACT:

Purpose

Mantle cell lymphoma (MCL) is a fatal subtype of non-Hodgkin lymphoma. SOX11 transcription factor is overexpressed in the majority of nodal MCL. We have previously reported that B cell-specific overexpression of SOX11 promotes MCL pathogenesis via critically increasing BCR signaling in vivo. SOX11 is an attractive target for MCL therapy; however, no small-molecule inhibitor of SOX11 has been identified to date. Although transcription factors are generally considered undruggable, the ability of SOX11 to bind to the minor groove of DNA led us to hypothesize that there may exist cavities at the protein-DNA interface that are amenable to targeting by small molecules.

Experimental design

Using a combination of in silico predictions and experimental validatio

SUBMITTER: Jatiani SS 

PROVIDER: S-EPMC8364871 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature