UPR^mt activation protects against MPP⁺-induced toxicity in a cell culture model of Parkinson's disease.

ABSTRACT: The pathogenesis of Parkinson's disease (PD) remains elusive, but mitochondrial dysfunction is believed to be one crucial step in its pathogenesis. The mitochondrial unfolded protein response (UPR^mt) is an important mitochondrial quality control strategy that maintains mitochondrial function in response to disturbances of mitochondrial protein homeostasis. Activation of the UPR^mt and the beneficial effect of rescuing mitochondrial proteostasis have been reported in several genetic models of PD. However, the pathogenic relevance of the UPR^mt in idiopathic PD is unknown. The present study examined the link between the UPR^mt and mitochondrial dysfunction in 1-methyl-4-phenylpyridinium (MPP⁺)-treated SH-SY5Y cells. Treatment with MPP 

SUBMITTER: Hu D 

PROVIDER: S-EPMC8364872 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature