Backward joint model and dynamic prediction of survival with multivariate longitudinal data.

ABSTRACT: An important approach to dynamic prediction of time-to-event outcomes using longitudinal data is based on modeling the joint distribution of longitudinal and time-to-event data. The widely used joint model for this purpose is the shared random effect model. Presumably, adding more longitudinal predictors improves the predictive accuracy. However, the shared random effect model can be computationally difficult or prohibitive when a large number of longitudinal variables are used. In this paper, we study an alternative way of modeling the joint distribution of longitudinal and time-to-event data. Under this formulation, the log-likelihood involves no more than one-dimensional integration, regardless of the number of longitudinal variables in the model. Therefore, this model is particularly s

SUBMITTER: Shen F 

PROVIDER: S-EPMC8364884 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature