Structural and Functional Default Mode Network Connectivity and Antipsychotic Treatment Response in Medication-Naive First Episode Psychosis Patients.

ABSTRACT:

Introduction

Only a few studies have comprehensively characterized default mode network (DMN) pathology on a structural and functional level, and definite conclusions cannot be drawn due to antipsychotic medication exposure and illness chronicity. The objective of this study was to characterize DMN pathology in medication-naïve first episode psychosis (FEP) patients, and determine if DMN structural and functional connectivity (FC) have potential utility as a predictor for subsequent antipsychotic treatment response.

Methods

Diffusion imaging and resting state FC data from 42 controls and 52 FEP were analyzed. Patients then received 16 weeks of antipsychotic treatment. Using region of interest analyses, we quantified FC of the DMN and structural integrity of the white matter

SUBMITTER: Maximo JO 

PROVIDER: S-EPMC8364918 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature