D-index as a marker of bloodstream infections in patients with allogeneic hematopoietic stem cell transplantation.

ABSTRACT:

Background

Neutropenia is a risk factor for development of infections; however, the direct effect of neutropenia on development of bloodstream infection (BSI) is not known. D-index, which is area between the neutrophil time curve and a neutrophil count of 0.5 × 10⁹ /L, incorporates the combined effect of severity and duration of neutropenia. We aimed to evaluate whether D-index can be used as a marker for BSI in patients with allogeneic stem cell transplantation.

Method

We conducted a retrospective cohort study of patients undergoing allogeneic stem cell transplantation between January 1, 2005, and September 30, 2015. The primary outcome measure was the development of BSI within 30 days of transplantation.

Results

A total of 714 patients were included in th

SUBMITTER: Vijayvargiya P 

PROVIDER: S-EPMC8364926 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature