A systematic review of historical and current trends in Chagas disease.

ABSTRACT:

Introduction

Chagas disease (CD) is caused by Trypanosoma cruzi. When acquired, the disease develops in stages. For diagnosis, laboratory confirmation is required, and an extensive assessment of the patient's health should be performed. Treatment consists of the administration of trypanocidal drugs, which may cause severe adverse effects. The objective of our systematic review was to analyze data contained in the CD published case reports to understand the challenges that patients and clinicians face worldwide.

Materials and methods

We performed a systematic review following the PRISMA guidance. PubMed database was explored using the terms 'American trypanosomiasis' or 'Chagas disease'. Results were limited to human case reports written in English or Spanish. A total

SUBMITTER: Alvarez-Hernandez DA 

PROVIDER: S-EPMC8365018 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature