Host Genetic Risk Factors for Chlamydia trachomatis-Related Infertility in Women.

ABSTRACT:

Background

Chlamydia trachomatis (Ct) infection ascending to the upper genital tract can cause infertility. Direct association of genetic variants as contributors is challenging because infertility may not be diagnosed until years after infection. Investigating the intermediate trait of ascension bridges this gap.

Methods

We identified infertility genome-wide association study (GWAS) loci using deoxyribonucleic acid from Ct-seropositive cisgender women in a tubal factor infertility study and Ct-infected cisgender women from a longitudinal pelvic inflammatory disease cohort with known fertility status. Deoxyribonucleic acid and blood messenger ribonucleic acid from 2 additional female cohorts with active Ct infection and known endometrial infection status were used to investi

SUBMITTER: Zheng X 

PROVIDER: S-EPMC8365119 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature