The role of voltage-gated chloride channels in the epileptogenesis of temporal lobe epilepsy.

ABSTRACT:

Background

Temporal lobe epilepsy (TLE) is the most common intractable epilepsy in adults, and elucidation of the underlying pathological mechanisms is needed. Voltage-gated chloride channels (ClC) play diverse physiological roles in neurons. However, less is known regarding their functions in the epilepogenesis of TLE.

Methods

ClC-mediated current and the spontaneous inhibitory synaptic currents (sIPSC) in hippocampal neurons of epileptic lesions were investigated by electrophysiological recording. The EEG data were analyzed by Z-scored wavelet and Fourier transformations. The expression of ClC-3, a member of ClC gene family, was detected by immunostaining and western blot.

Findings

ClC-mediated current was increased in the hippocampal neurons of chronic TLE mice. Ap

SUBMITTER: Shen KF 

PROVIDER: S-EPMC8365373 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature