Parental Bacillus Calmette-Guerin vaccine scars decrease infant mortality in the first six weeks of life: A retrospective cohort study.

ABSTRACT:

Background

Live attenuated vaccines have been observed to have particularly beneficial effects for child survival when given in the presence of maternally transferred immunity (priming). We aimed to test this finding and furthermore explore the role of paternal priming.

Methods

In an exploratory, retrospective cohort study in 2017, parental Bacillus Calmette-Guérin (BCG) scars were assessed for infants from the Bandim Health Project (BHP) who had participated in a 2008-2013 trial of neonatal BCG vaccination. Parental scar effects on mortality were estimated from birth to 42 days, the age of the scheduled diphtheria-tetanus-pertussis (DTP) vaccination, in Cox proportional hazard models adjusted with Inverse Probability of Treatment Weighting.

Findings

For 66% (510/772)

SUBMITTER: Berendsen M 

PROVIDER: S-EPMC8365433 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature