Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia.

ABSTRACT:

Objective

Cancer-associated cachexia is a devastating pathological disorder characterized by skeletal muscle wasting and fat storage depletion. Circular RNA, a newly discovered class of noncoding RNAs with important roles in regulating lipid metabolism, has not been fully understood in the pathology of cachexia. We aimed to identify circular RNAs that are upregulated in adipose tissues from cachectic patients and explore their function and mechanism in lipid metabolism.

Methods

Whole transcriptome RNA sequencing was used to screen for differentially expressed circRNAs. Quantitative reverse transcription PCR was applied to detect the expression level of circPTK2 in adipose tissues. The diagnostic value of circPTK2 was evaluated in adipose tissues from patients with and withou

SUBMITTER: Ding Z 

PROVIDER: S-EPMC8365522 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature