Adenovirus is prevalent in juvenile polyps and correlates with low vitamin D receptor expression.

ABSTRACT:

Background

The objective of this study was to assess human adenovirus (HAdV) infection in juvenile polyps (JPs) and to preliminarily establish a correlation to vitamin D receptor (VDR) expression.

Methods

The study includes 76 patients of 5.2 ± 2.8 years old. Seventy-eight JP specimens and 24 parapolyp tissues from polypectomy were used. PCR was used to detect HAdV DNA and quantitative reverse transcription-PCR for viral and host gene expression. The PCR products were sequenced for virus typing. The correlation between VDR expression and HAdV infection was established using nonparametric Spearman's analysis.

Results

Seventy-four children (97.4%) had a single polyp and two had two polyps. The histopathological characteristics of the polyps were in line with JP. Thirty-

SUBMITTER: Wang L 

PROVIDER: S-EPMC8365564 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature