An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration.

ABSTRACT:

Background

The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract infections in humans is not well understood. Here, we sought to identify epigenetic and transcriptomic features of cytokine production capacity in circulating monocytes during community-acquired pneumonia (CAP).

Methods

Circulating CD14+ monocytes were obtained from the blood of CAP patients included in a longitudinal, observational cohort study, on hospitalization (acute stage, n=75), and from the same patients after a 1-month follow-up (recovery stage, n=56). Age and sex-matched non-infectious participants were included as controls

SUBMITTER: Brands X 

PROVIDER: S-EPMC8365568 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature