Fasciola hepatica products can alter the response of bovine immune cells to Mycobacterium avium subsp. paratuberculosis.

ABSTRACT:

Background

Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties.

Objectives

Given the importance of the T helper 1 (Th1) immune response in controlling infections with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle, we aimed to establish the immunological consequences that co-infection with F. hepatica might have on the course of Johne's disease (JD).

Methods

This study compared the in vitro response of bovine immune cells to infection with MAP or exposure to MAP antigens following F. hepatica infection or stimulation with F. hepatica products.

Results

We found a decreased proliferation of peripheral

SUBMITTER: Naranjo-Lucena A 

PROVIDER: S-EPMC8365740 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature