Signal detection of drospirenone-containing oral contraceptives: a disproportionality analysis using the Korea Adverse Event Reporting System Database, 2008-2017.

ABSTRACT:

Objectives

To detect the signals for drospirenone-containing oral contraceptives (DCOCs) and describe the reporting pattern of adverse events (AEs) caused by DCOCs compared with levonorgestrel/desogestrel/gestodene-containing (second/third generation) oral contraceptives.

Design

A descriptive analysis of claims data.

Setting

The Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System Database from 1 February 2008 to 31 December 2017.

Outcome measures

Signals for DCOCs were identified using three data mining indices. The characteristics, death cases, and the annual pattern of AE reports were compared between DCOCs and second/third generation oral contraceptives.

Results

Of the 242 DCOC-related AEs, 54 signals were detected an

SUBMITTER: Lee Y 

PROVIDER: S-EPMC8365811 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature