Parasite worm antigens instruct macrophages to release immunoregulatory extracellular vesicles.

ABSTRACT: Emerging evidence suggests that immune cells not only communicate with each other through cytokines, chemokines, and cell surface receptors, but also by releasing small membranous structures known as extracellular vesicles (EVs). EVs carry a variety of different molecules that can be taken up by recipient cells. Parasitic worms are well known for their immunomodulatory properties, but whether they can affect immune responses by altering EV-driven communication between host immune cells remains unclear. Here we provide evidence that stimulation of bone marrow-derived macrophages (BMDMs) with soluble products of Trichuris suis (TSPs), leads to the release of EVs with anti-inflammatory properties. Specifically, we found that EVs from TSP-pulsed BMDMs, but not those from unstimulated BM

SUBMITTER: Zakeri A 

PROVIDER: S-EPMC8365858 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature