Perioperative Intravenous Lidocaine and Metastatic Cancer Recurrence - A Narrative Review.

ABSTRACT: Cancer is a major global health problem and the second leading cause of death worldwide. When detected early, surgery provides a potentially curative intervention for many solid organ tumours. Unfortunately, cancer frequently recurs postoperatively. Evidence from laboratory and retrospective clinical studies suggests that the choice of anaesthetic and analgesic agents used perioperatively may influence the activity of residual cancer cells and thus affect subsequent recurrence risk. The amide local anaesthetic lidocaine has a well-established role in perioperative therapeutics, whether used systemically as an analgesic agent or in the provision of regional anaesthesia. Under laboratory conditions, lidocaine has been shown to inhibit cancer cell behaviour and exerts beneficial effects on co

SUBMITTER: Wall TP 

PROVIDER: S-EPMC8365881 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature