Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants.

ABSTRACT:

Background

Failing of intrinsic chondrocyte repair after mechanical stress is known as one of the most important initiators of osteoarthritis. Nonetheless, insight into these early mechano-pathophysiological processes in age-related human articular cartilage is still lacking. Such insights are needed to advance clinical development. To highlight important molecular processes of osteoarthritis mechano-pathology, the transcriptome-wide changes following injurious mechanical stress on human aged osteochondral explants were characterized.

Methods

Following mechanical stress at a strain of 65% (65%MS) on human osteochondral explants (n_65%MS = 14 versus n_control = 14), RNA sequencing was performed. Differential expression analysis between control and 65%MS wa

SUBMITTER: Houtman E 

PROVIDER: S-EPMC8365911 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature