Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma.

ABSTRACT:

Background

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities. Merkel cell tumors display with neuroendocrine features and Merkel cell polyomavirus (MCPyV) infection in the majority (80%) of patients. Although loss of histone H3 lysine 27 trimethylation (H3K27me3) has been shown during MCC tumorigenesis, epigenetic dysregulation has largely been overlooked.

Methods

We conducted global DNA methylation profiling of clinically annotated MCC primary tumors, metastatic skin tumors, metastatic lymph node tumors, paired normal tissues, and two human MCC cell lines using the Illumina Infinium EPIC DNA methylation BeadArray platform.

Results

Significant differential DNA methylation patterns across the genome are revealed betwe

SUBMITTER: Gujar H 

PROVIDER: S-EPMC8365948 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature