⁶⁸Ga-DOTATATE PET-CT as a tool for radiation planning and evaluating treatment responses in the clinical management of meningiomas.

ABSTRACT:

Background and purpose

Meningiomas express the somatostatin receptor (SSTR), which normal bone and brain lack. PET imaging with SSTR ligands such as ⁶⁸ Ga-DOTATATE have been recently shown to aid in the imaging and identification of menginiomas. We hypothesize that ⁶⁸ Ga-DOTATATE PET/CT in conjunction with MRI aids in radiation (RT) target volume delineation and evaluating treatment response.

Materials and methods

Nineteen patients with meningiomas underwent ⁶⁸ Ga-DOTATATE PET/CT and MRI for RT planning and/or post-treatment follow-up. Meningiomas were grade I (n = 9) or not biopsied (n = 8) and frequently involved base of skull (n = 10). Ten (53%) patients received post-operative RT and 9 (47%) received fractaionted RT. In the subgroup that

SUBMITTER: Kowalski ES 

PROVIDER: S-EPMC8365988 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature