Two progressed malignant phyllodes tumors of the breast harbor alterations in genes frequently involved in other advanced cancers.

ABSTRACT:

Background

The genomic landscape of phyllodes tumors (PTs) of the breast is not well defined, especially in patients with advanced disease. To shed light on this topic, paired primary and progressed tumor samples from two patients with malignant PTs were subjected to next-generation sequencing (NGS) followed by functional analysis of genetic alterations using two prediction tools.

Methods

The DNA of both the primary tumor and distant metastases of Patient 1 and the primary and recurrent tumor of Patient 2 were subjected to molecular profiling. NGS with the FoundationOne® assay was performed in a commercial molecular pathology laboratory. Two in silico prediction tools were used to estimate the pathogenicity of indicated genetic alterations.

Results

In total, 38 genomi

SUBMITTER: Reinisch M 

PROVIDER: S-EPMC8365991 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature