Dataset Information

COVID-19 severity and outcome in multiple sclerosis: Results of a national, registry-based, matched cohort study.

ABSTRACT:

Background

Risk factors associated with coronavirus disease 2019 (COVID-19) severity in patients with multiple sclerosis (MS) have been described. Recent improvements in supportive care measures and increased testing capacity may modify the risk of severe COVID-19 outcome in MS patients. This retrospective study evaluates the severity and outcome of COVID-19 in MS and characterizes temporal trends over the course of the pandemic in the United States.

Methods

We conducted a comparative cohort study using de-identified electronic health record (EHR) claims-based data. MS patients diagnosed with COVID-19 between February 2, 2020 and October 13, 2020 were matched (1:2) to a control group using propensity score analysis. The primary outcome was a composite of intensive care unit (ICU) admission, mechanical ventilation, and/or death.

Results

A total of 2,529 patients (843 MS and 1,686 matched controls) were included. Non-ambulatory and pre-existing comorbidities were independent risk factors for COVID-19 severity. The risk for the severe composite outcome was lower in the late cohorts compared with the early cohorts.

Conclusions

The majority of MS patients actively treated with a disease-modifying therapy (DMT) had mild disease. The observed trend toward a reduction in severity risk in recent months suggests an improvement in COVID-19 outcome.

SUBMITTER: Perez CA

PROVIDER: S-EPMC8366056 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

COVID-19 severity and outcome in multiple sclerosis: Results of a national, registry-based, matched cohort study.

Pérez Carlos A CA Zhang Guo-Qiang GQ Li Xiaojin X Huang Yan Y Lincoln John A JA Samudralwar Rohini D RD Gupta Rajesh K RK Lindsey John W JW

Multiple sclerosis and related disorders 20210816

<h4>Background</h4>Risk factors associated with coronavirus disease 2019 (COVID-19) severity in patients with multiple sclerosis (MS) have been described. Recent improvements in supportive care measures and increased testing capacity may modify the risk of severe COVID-19 outcome in MS patients. This retrospective study evaluates the severity and outcome of COVID-19 in MS and characterizes temporal trends over the course of the pandemic in the United States.<h4>Methods</h4>We conducted a compara ...[more]

PMID: 34418735

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Dataset Information

COVID-19 severity and outcome in multiple sclerosis: Results of a national, registry-based, matched cohort study.

Background

Methods

Results

Conclusions

Publications

COVID-19 severity and outcome in multiple sclerosis: Results of a national, registry-based, matched cohort study.

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