Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer.

ABSTRACT:

Background

Epidermal growth factor receptor-mutated (EGFR⁺) non-small-cell lung cancer (NSCLC) patients failing tyrosine kinase inhibitors (TKI) can benefit from next-line targeted therapies, but implementation is challenging.

Methods

EGFR⁺ NSCLC patients treated with first/second-generation (1G/2G) TKI at our institution with a last follow-up after osimertinib approval (February 2016), were analyzed retrospectively, and the results compared with published data under osimertinib.

Results

A total of 207 patients received erlotinib (37%), gefitinib (16%) or afatinib (47%). The median age was 66 years, with a predominance of female (70%), never/light-smokers (69%). T790M testing was performed in 174/202 progressive cases (86%), positive in 93/174 (5

SUBMITTER: Magios N 

PROVIDER: S-EPMC8366107 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature