Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.

ABSTRACT:

Background

Therapeutic treatment options for chronic autoimmune disorders such as multiple sclerosis (MS) rely largely on the use of non-specific immunosuppressive drugs, which are not able to cure the disease. Presently, approaches to induce antigen-specific tolerance as a therapeutic approach; for example, by peptide-based tolerogenic 'inverse' vaccines have regained great interest. We have previously shown that coupling of peptides to carriers can enhance their capacity to induce regulatory T cells in vivo.

Method

In this present study, we investigated whether the tolerogenic potential of immunodominant myelin T-cell epitopes can be improved by conjugation to the synthetic carrier polyethylene glycol (PEG) in an experimental autoimmune encephalomyelitis (EAE) mouse

SUBMITTER: Pfeil J 

PROVIDER: S-EPMC8366199 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature