Anticarin β Inhibits Human Glioma Progression by Suppressing Cancer Stemness via STAT3.

ABSTRACT: Glioma is the most common form of malignant brain cancer. It is very difficult to cure malignant glioma because of the presence of glioma stem cells, which are a barrier to cure, have high tumorigenesis, associated with drug resistance, and responsible for relapse by regulating stemness genes. In this study, our results demonstrated that anticarin β, a natural compound from Antiaris toxicaria, can effectively and selectively suppress proliferation and cause apoptosis in glioma cells, which has an IC₅₀ that is 100 times lower than that in mouse normal neural stem cells. Importantly, cell sphere formation assay and real time-quantitative analysis reveal that anticarin β inhibits cancer stemness by modulating related stemness gene expression. Additionally, anticarin β induce

SUBMITTER: Zhang M 

PROVIDER: S-EPMC8366317 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature