Shifts in Gait Signatures Mark the End of Lifespan in Mice, With Sex Differences in Timing.

ABSTRACT: Reduced walking speed is a hallmark of functional decline in aging across species. An age-related change in walking style may represent an additional key marker signifying deterioration of the nervous system. Due to the speed dependence of gait metrics combined with slowing of gait during aging, it has been challenging to determine whether changes in gait metrics represent a change in style. In this longitudinal study we employed gait signatures to separate changes in walking style and speed in mice. We compared gait signatures at mature adult age with middle aged, old and geriatric time points and included female and male sub-cohorts to examine sex differences in nature or timing signature shifts. To determine whether gait signature shifts occurred independently from a decline in other mo

SUBMITTER: Broom L 

PROVIDER: S-EPMC8366415 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature