Ontology highlight
ABSTRACT:
SUBMITTER: Jarroux J
PROVIDER: S-EPMC8366456 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Jarroux Julien J Foretek Dominika D Bertrand Claire C Gabriel Marc M Szachnowski Ugo U Saci Zohra Z Guo Shuling S Londoño-Vallejo Arturo A Pinskaya Marina M Morillon Antonin A
EMBO reports 20210506 7
Epithelial-to-mesenchymal transition (EMT) describes the loss of epithelial traits and gain of mesenchymal traits by normal cells during development and by neoplastic cells during cancer metastasis. The long noncoding RNA HOTAIR triggers EMT, in part by serving as a scaffold for PRC2 and thus promoting repressive histone H3K27 methylation. In addition to PRC2, HOTAIR interacts with the LSD1 lysine demethylase, an epigenetic regulator of cell fate during development and differentiation, but littl ...[more]