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Nanoscale Catalyst Chemotaxis Can Drive the Assembly of Functional Pathways.


ABSTRACT: Recent experiments demonstrate molecular chemotaxis or altered diffusion rates of enzymes in the presence of their own substrates. We show here an important implication, namely, that if a nanoscale catalyst A produces a small-molecule ligand product L which is the substrate of another catalyst B, the two catalysts will attract each other. We explore this nonequilibrium producer recruitment force (ProRec) in a reaction-diffusion model. The predicted cat-cat association will be the strongest when A is a fast producer of L and B is a tight binder to it. ProRec is a force that could drive a mechanism (the catpath mechanism) by which catalysts could become spatially localized into functional pathways, such as in the biochemical networks in cells, which can achieve complex goals.

SUBMITTER: Kocher C 

PROVIDER: S-EPMC8366527 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Nanoscale Catalyst Chemotaxis Can Drive the Assembly of Functional Pathways.

Kocher Charles C   Agozzino Luca L   Dill Ken K  

The journal of physical chemistry. B 20210729 31


Recent experiments demonstrate molecular chemotaxis or altered diffusion rates of enzymes in the presence of their own substrates. We show here an important implication, namely, that if a nanoscale catalyst A produces a small-molecule ligand product L which is the substrate of another catalyst B, the two catalysts will attract each other. We explore this nonequilibrium producer recruitment force (ProRec) in a reaction-diffusion model. The predicted cat-cat association will be the strongest when  ...[more]

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