External Validations of Cardiovascular Clinical Prediction Models: A Large-Scale Review of the Literature.

ABSTRACT:

Background

There are many clinical prediction models (CPMs) available to inform treatment decisions for patients with cardiovascular disease. However, the extent to which they have been externally tested, and how well they generally perform has not been broadly evaluated.

Methods

A SCOPUS citation search was run on March 22, 2017 to identify external validations of cardiovascular CPMs in the Tufts Predictive Analytics and Comparative Effectiveness CPM Registry. We assessed the extent of external validation, performance heterogeneity across databases, and explored factors associated with model performance, including a global assessment of the clinical relatedness between the derivation and validation data.

Results

We identified 2030 external validations of 1382 CPMs. E

SUBMITTER: Wessler BS 

PROVIDER: S-EPMC8366535 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature