MCM5 Aggravates the HDAC1-Mediated Malignant Progression of Lung Cancer.

ABSTRACT:

Background

Histone deacetylase 1 (HDAC1) is essential in the malignant progression of tumors. However, there is no obvious relationship between the expression of HDAC1 and the survival of lung cancer patients. Herein, we explored the involvement of minichromosome maintenance complex component 5 (MCM5) and HDAC1 interaction in the epithelial-to-mesenchymal transition (EMT)-dependent malignant progression of lung cancer.

Methods

We analyzed the expression of MCM5 and HDAC1 in The Cancer Genome Atlas database and clinical samples, as well as their impact on patient survival. Cell and animal experiments were performed to verify the promotion of EMT in lung cancer cells mediated by MCM5 and HDAC1.

Results

We found that lung adenocarcinoma patients with high expression of M

SUBMITTER: Zhang LL 

PROVIDER: S-EPMC8366603 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature