Imaging biomarker dynamics in an intracranial murine glioma study of radiation and antiangiogenic therapy.

ABSTRACT:

Purpose

There is a growing need for noninvasive biomarkers to guide individualized spatiotemporal delivery of radiation therapy (RT) and antiangiogenic (AA) therapy for brain tumors. This study explored early biomarkers of response to RT and the AA agent sunitinib (SU), in a murine intracranial glioma model, using serial magnetic resonance imaging (MRI).

Methods and materials

Mice with MRI-visible tumors were stratified by tumor size into 4 therapy arms: control, RT, SU, and SU plus RT (SURT). Single-fraction conformal RT was delivered using MRI and on-line cone beam computed tomography (CT) guidance. Serial MR images (T2-weighted, diffusion, dynamic contrast-enhanced and gadolinium-enhanced T1-weighted scans) were acquired biweekly to evaluate tumor volume, apparent diffusi

SUBMITTER: Chung C 

PROVIDER: S-EPMC8366682 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature