A roadmap to using randomization in clinical trials.

ABSTRACT:

Background

Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups with respect to important known and unknown confounders, and contributes to the validity of statistical tests. Various restricted randomization procedures with different probabilistic structures and different statistical properties are available. The goal of this paper is to present a systematic roadmap for the choice and application of a restricted randomization procedure in a clinical trial.

Methods

We survey available restricted randomization procedures for sequential allocation of subjects in a randomized, comparative, parallel group clinical trial with equal (1:1) allocation. We explore statistical pro

SUBMITTER: Berger VW 

PROVIDER: S-EPMC8366748 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature