The Archaeal Na⁺/Ca²⁺ Exchanger (NCX_Mj) as a Model of Ion Transport for the Superfamily of Ca²⁺/CA Antiporters.

ABSTRACT: The superfamily of Calcium/Cation (Ca²⁺/CA) antiporters extrude Ca²⁺ from the cytosol or subcellular compartments in exchange with Na⁺, K⁺, H⁺, Li⁺, or Mg²⁺ and thereby provide a key mechanism for Ca²⁺ signaling and ion homeostasis in biological systems ranging from bacteria to humans. The structure-dynamic determinants of ion selectivity and transport rates remain unclear, although this is of primary physiological significance. Despite wide variances in the ion selectivity and transport rates, the Ca²⁺/CA proteins share structural motifs, although it remains unclear how the ion recognition/binding is coupled to the ion translocation events. Here, the archaeal Na⁺/Ca²⁺ e

SUBMITTER: Khananshvili D 

PROVIDER: S-EPMC8366772 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature