Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm.

ABSTRACT:

Background and purpose

The incidences of intracranial aneurysm and aneurysmal subarachnoid hemorrhage are high in postmenopausal women. Although population-based studies suggest that hormone replacement therapy is beneficial for postmenopausal women with intracranial aneurysms, estrogen replacement may no longer be recommended for the prevention of chronic diseases given its association with adverse outcomes, such as cancer and ischemic stroke. The isoflavone daidzein and its intestinal metabolite equol are bioactive phytoestrogens and potent agonists of estrogen receptors. Given their estrogenic properties, we investigated whether the isoflavones daidzein and equol are protective against the formation and rupture of intracranial aneurysms in a mouse model of the postmenopausal sta

SUBMITTER: Yokosuka K 

PROVIDER: S-EPMC8366789 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature